Cobalamins And The Allergic Response
Cobalamins are a set of unique natural chemicals that belong to the vitamin B12 family. One property that makes cobalamins unique is that they contain a cobalt molecule – in fact, cobalamins are the only known natural substances utilized by the human body that contain cobalt as its central structure.
The unique properties of cobalamins enables them to regulate cells in your immune system that produce IgE antibodies so these cells don’t over-produce more IgE than your body needs for normal, healthy immune functioning. Antibodies play an important role in protecting your body against foreign invading substances that can be dangerous – such as viruses or bacteria.
Every person has an immune system whose purpose is to keep them healthy. You want your immune system to respond to dangerous foreign substances – like viruses or bacteria – and help your body fight off harmful invaders. But you don’t want your immune system to over-react and go into overdrive trying to fight substances that are not harmful – like the feathers in your pillow, or your cat, or pollen.
Here’s What’s Really Happening:
Your immune system includes an opposing set of cells called ‘T-cells’. One type of T-cell is the TH2 “Aggressor Cell”; this causes your immune system to produce a key allergen antibody called Immunoglobulin E (IgE) (pronounced EYE-gee-EEE). The more TH2 Aggressor Cells you have, and the more active they are, the more IgE you produce. You also have cells called TH1 “Suppressor Cells”, and these cells dampen and ‘down-regulate’ the overproduction of IgE. The more active your TH1 Suppressor Cells are, the LESS IgE your body will produce.
So why is this IgE so important? Simply this: IgE is the main culprit in the pathway to your body releasing histamine when you’re exposed to allergens. And since histamine is an inflammatory chemical, it’s what your body is reacting to with all those annoying symptoms. So you want to release as little histamine as possible when you’re exposed to pollen or other allergens.
Dr. Ratner says: “It’s not the pollen, it’s the histamine.” And he’s right. That’s why people run to the store to buy an ANTI-histamine. They don’t buy an anti-DOG, or an anti-POLLEN!
When you are first exposed to various allergens (like pollen), your immune system creates IgE antibodies for those specific allergens.
These IgE antibodies attach themselves to mast cells in your nasal and sinus cavities, and there they sit, waiting for allergens to come along. And when allergens, like pollen, do come along, they bind to the IgE molecules which in turn causes the mast cells to explode and release a flood of inflammatory histamine, which is linked to all those allergy symptoms.
The Action Of Cobalamins On IgE Over-Production And Histamine Release
Since IgE levels is the main culprit in the pathway to your body releasing histamine when you’re exposed to allergens, and because histamine is an inflammatory chemical, it’s what your body is reacting to with all those annoying symptoms. The ideal, or normal response is to release as little histamine as possible when you’re exposed to pollen or other allergens.
Cobalamins have been shown to “down-regulate” the over-production of IgE by the TH2 Aggressor Cells, and stimulate the dampening activity of the TH1 Suppressor Cells. It is the combination of lowered activity of TH2 Aggressor Cells and the increased functioning of TH1 Suppressor Cells which results in the lowering of the over-production of IgE which is linked to the hypersensitive release of histamine, which, in turn, is linked to allergy symptoms.
This is how AllergX works: by administering a clinically appropriate dosage of cobalamins, AllergX works to down-regulate over-production of IgE and, as Dr. Paul H. Ratner, MD says: “restore a normal response to seasonal and year-round allergens, which is NO ALLERGIC RESPONSE AT ALL!”